References & Legals

References: 1. SBR PROTECT® package leaflet. September 2024. 2. SBR REPAIR® package leaflet. September 2024. 3. Test Report 21 39 00123, June 2021, Use test assessment of the efficacy skin moisture and transepidermal water loss. 4. Mortz CG, Andersen KE, Halkier‐Sorensen L. The efficacy of different moisturizers on barrier recovery in hairless mice evaluated by non‐invasive bioengineering methods: A model to select the potentially most effective product. Contact Dermatitis. 1997 Jun;36(6):297-301. 5. Kynemund L, Jemec GB, Wulf HC. Moisturisers for Psoriatic Skin–Do Gross Morphological Differences Matter?. Skin Pharmacology and Applied Skin Physiology. 2001;14(1):20-6. 6. Berardesca E, Barbareschi M, Veraldi S, Pimpinelli N. Evaluation of efficacy of a skin lipid mixture in patients with irritant contact dermatitis, allergic contact dermatitis or atopic dermatitis: a multicenter study. Contact Dermatitis. 2001 Nov;45(5):280-5. 7. Del Rosso J, Zeichner J, Alexis A, Cohen D, Bernson D. Understanding the Epidermal Barrier in Healthy and Compromised Skin: Clinically Relevant Information for the Dermatology Practitioner. Proceedings of an Expert Panel Roundtable Meeting. J Clin Aesthetic Dermatol 2016;9(4; Suppl 1):S2-S8. 8. Man MQ, Feingold KR, Thornfeldt CR, Elias PM. Optimization of Physiological Lipid Mixtures for Barrier Repair. J. Invest. Dermatol. 1996;106(5):1096-101. 9. Kucharekova M, Schalkwijk J, Van De Kerkhof PC, Van De Valk PG. Effect of a lipid‐rich emollient containing ceramide 3 in experimentally induced skin barrier dysfunction. Contact Dermatitis. 2002 Jun;46(6):331-8. 10. Halkier-Sørensen L. Efficacy of skin care products and different mixtures of lipids on barrier function.In Dermatopharmacology of Topical Preparations 2000 (pp. 329-363). Springer, Berlin, Heidelberg. 11. Adcock Ingram Data on File. 12. Adcock Ingram Data on File. 13. Kakadia PG, Conway BR. Solid Lipid Nanoparticles: A Potential Approach for Dermal Drug Delivery. Am J Pharmacol Sci 2014;2(5A):1-7. 14. Mortz CG, Andersen KE, Halkier‐Sorensen L. The efficacy of different moisturizers on barrier recovery in hairless mice evaluated by non‐invasive bioengineering methods: A model to select the potentially most effective product. Contact Dermatitis. 15. Kynemund L, Jemec GB, Wulf HC. Moisturisers for Psoriatic Skin–Do Gross Morphological Differences Matter?. Skin Pharmacology and Physiology. 2001;14(1):20-6. 16. Berardesca E, Barbareschi M, Veraldi S, Pimpinelli N. Evaluation of efficacy of a skin lipid mixture in patients with irritant contact dermatitis, allergic contact dermatitis or atopic dermatitis: a multicenter study. Contact Dermatitis. 2001 Nov;45(5):280-5. 17. Kucharekova M, Van De Kerkhof PC, Van Der Valk PG. A randomized comparison of an emollient containing skin‐related lipids with a petrolatum‐based emollient as adjunct in the treatment of chronic hand dermatitis. Contact dermatitis. 2003 Jun;48(6):293-9. 18. Namazova-Baranova LS, Vishneva EA, Torshhoeva RM, Dzagoeva ZN, Alexeeva AA, Levina JG, Efendieva KE, Voznesenskaya NI, Aslamyazyan LK. Nonsteroidal topical medications in the treatment of atopic dermatitis in children. Pediatr Pharmacol. 2012;9:66-70. 19. Mortensen JT, Bjerring P, Cramers M. Locobase REPAIR® cream following CO2 laser skin resurfacing reduces interstitial fluid oozing. Journal of Cutaneous Laser Therapy. 2001 Jan 1;3(3):155-8. 20. Allergy Foundation of South Africa. Who is AFSA? Accessed on 13 May 2025. Available from https://www.allergyfoundation.co.za/. 21. Dhabale A, Nagpure S. Types of Psoriasis and Their Effects on the Immune System. Cureus. 2022 Sep 24;14(9). 22. National Eczema Association. What is Eczema? Accessed on 13 May 2025. Available from: https://nationaleczema.org/eczema/. 23. Hunzeker CM, Weiss ET, Geronemus RG. Fractionated CO2 laser resurfacing: our experience with more than 2000 treatments. Aesthetic Surgery Journal. 2009 Jul 1;29(4):317-22. 24. SBR RENEW® package leaflet. May, 2023. 25. Data on file. 26. Karo Pharma. Proof of the Effect, Locobase Protect Cream, January 2023.

Under licence from Karo Healthcare Stockholm, Sweden. Adcock Ingram Limited. Co. Reg. No. 1949/034385/06. Private Bag X69, Bryanston, 2021, South Africa. Customer Care: 0860 ADCOCK / 232625. www.adcock.com. 03.12.20251000001547 May 2025